C-Reactive Protein, but not Low-Density Lipoprotein Cholesterol Levels, Associate with Coronary Atheroma Regression and Cardiovascular Events Following Maximally Intensive Statin Therapy
نویسندگان
چکیده
Dept of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH; Cardiovascular Division, Brigham and Women’s Hospital, Boston, MA; C5Research, Cleveland Clinic, Cleveland, OH; Section of Cardiovascular Research, Baylor College of Medicine, and the Methodist DeBakey Heart and Vascular Center, Houston, TX; Centre for Vascular Research, University of New South Wales, Sydney, Australia; INSERM Dyslipidaemia and Atherosclerosis Research Unit, Hôpital de la Pitié, Paris, France; West German Heart Center, Essen, Germany; AstraZeneca, Wilmington, DE; South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia
منابع مشابه
C-reactive protein, but not low-density lipoprotein cholesterol levels, associate with coronary atheroma regression and cardiovascular events after maximally intensive statin therapy.
BACKGROUND Baseline C-reactive protein (CRP) levels predict major adverse cardiovascular events (MACE: death, myocardial infarction, stroke, coronary revascularization, and hospitalization for unstable angina). The association between changes in CRP levels with plaque progression and MACE in the setting of maximally intensive statin therapy is unknown. METHODS AND RESULTS The Study of Coronar...
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AIMS To evaluate the effect of long-term maximally intensive statin therapy on indices of coronary atheroma composition in a randomized trial, and how these changes relate to modifications of serum lipoproteins and systemic inflammation. METHODS AND RESULTS The Study of coronary Atheroma by inTravascular Ultrasound: the effect of Rosuvastatin vs. atorvastatiN (SATURN) employed serial intravas...
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AIMS The impact of baseline coronary plaque burden on the clinical outcome in patients receiving aggressive low-density lipoprotein cholesterol (LDL-C) lowering therapy to levels <70 mg/dL is unknown. We assessed the prognostic significance of baseline coronary plaque burden following high-intensity statin therapy. METHODS AND RESULTS SATURN used serial intravascular ultrasound (IVUS) to meas...
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BACKGROUND Statins reduce adverse cardiovascular outcomes and slow the progression of coronary atherosclerosis in proportion to their ability to reduce low-density lipoprotein (LDL) cholesterol. However, few studies have either assessed the ability of intensive statin treatments to achieve disease regression or compared alternative approaches to maximal statin administration. METHODS We perfo...
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Relationship between coronary plaque progression , as determined by intravascular ultrasound (IVUS), and prospective risk for cardiovascular events has been proven by the analysis of six clinical trials 1). IVUS studies showed only a minimal improvement of atheroma volume with statin therapy 2). A meta-analysis of nine studies using virtual histology IVUS (VH-IVUS) imaging with 16 treatment arm...
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